The purpose of this study is to identify bias-adjusted efficiency estimates and the determinants of efficiency in the Marine-Bio industry. Efficiency was estimated using the Bootstrap-DEA model, and efficiency determinants were analyzed by utilizing the dependent variables such as company age, number of employees, location within Marine-Bio clusters, R&D performance, and debt ratio. The efficiency analysis revealed that most of the DMUs belonged to the inefficient group with efficiency values below 0.7. The primary cause of inefficiency was identified as pure technical efficiency, which reflects the effectiveness of input combinations. In the analysis of efficiency determinants, it was found that the number of employees and the debt ratio had a positive (+) effect on efficiency. Conversely, engaging in R&D activities was found to have a negative (-) effect on efficiency.